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Current Proposals

 Current Proposals

In addition to the main grant aims, investigators associated with GECCO are pursuing other analyses. Proposed analyses are reviewed and approved by the relevant study PIs and completed in coordination with the Coordinating Center. The submission of a paper concept proposal is the first step in initiating a new analysis.

Approved proposals are listed, below, and you can click on each title to learn more about the proposal. If you have further questions, please contact the lead authors of the proposals or the GECCO Coordinating Center at gecco@fredhutch.org
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Description
  
Gene-set enrichment analysis of colon cancer genome- wide association data
  
Comprehensive Colorectal Cancer Risk Prediction To Inform Personalized Screening
  
Multi-stage clonal-expansion model (theoretical)
  
Association of any cancer susceptibility loci with risk of CRC
  
Association between ulcerative colitis and Crohn's disease susceptibility loci and risk of CRC
  
Genome-wide Scan of Copy Number Variation and Risk of Colorectal Cancer
  
Association of polymorphisms in PTGS1 and PTGS2 genes with colorectal cancer (CRC) risk and survival, and interactions with nonsteroidal anti-inflammatory drugs (NSAIDs)
  
Candidate pathway analysis for hormone-related genes
  
Gene-environment interaction for previously identified CRC susceptibility loci
  
Site-specific differential risks by site in the proximal colon, distal colon, and rectum
  
GxG Interaction Genome-wide Analysis
  
The association between colorectal cancer and genetic markers for circulating vitamin D.
  
Genome-wide survival analysis of all cause and colorectal cancer specific mortality in colorectal cancer cases
  
Gene-environment interaction of candidate pathway genes and menopausal hormone therapy
  
N/A
  
Polymorphisms in innate immunity genes and the risk of colorectal adenoma and cancer
  
Genetic variation in inflammatory pathways and survival
  
Genetic Loci associated with Colorectal Cancer and Inflammation pathways; interactions with nonsteroidal anti- inflammatory drugs
  
Interaction between colorectal cancer risk alleles, N-acetyl transferase genotypes, and red meat intake in relation to colorectal cancer risk
  
Modification of menopausal hormone therapy associated colorectal cancer risk by polymorphisms in candidate genes related to hormone metabolism, signaling and transport.
  
Identifying susceptibility loci that affect multiple different cancer sites by using a subset-based approach with improved power for combined analysis of heterogeneous traits
  
A Mendelian randomization study of LDL levels and the risk of colorectal cancer
  
Exploration of epistatic effects between genes of the acid arachidonic acid/cytochrome P450 pathway in interaction with environmental factors
  
Association between type 2 diabetes (T2D) susceptibility loci and colorectal cancer (CRC) risk and assessment of cancer-specific and overall survival - replication and exploration
  
Gene-environment interaction analysis between smoking phenotypes and common genetic variants across the genome
  
Smoking and Colorectal Cancer
  
Association between genetic variation and circulating selenium concentrations
  
Alcohol Intake and Genetic Variation
  
Genetic variation in epigenome regulatory pathways and the risk of colorectal cancer
  
Investigating Inflammation Pathways Across Multiple Cancer Sites
  
Gene-environment interaction analysis between aspirin/NSAIDs use and common genetic variants across the genome
  
Incorporating family history in genome-wide association studies for colorectal cancer.
  
Gene-environment interaction analysis between hormone replacement therapy use and common genetic variants across the genome with the risk of colorectal cancer.
  
Gene-environment interaction analysis of anthropometry phenotypes and diabetes with common genetic variants across the genome
  
Pooling-based GWAS for the identification of genes predisposing to sporadic colorectal cancers – Phase II
  
Gene-environment interaction for newly identified CRC susceptibility loci
  
Genetic polymorphisms in AR, ESR1, ESR2, and PGR and colorectal cancer survival in postmenopausal women
  
Integration of Gene Expression into Genome-wide Scans to Identify Novel Genetic Susceptibility Variants for Colorectal Cancer
  
Mutual replication of top genetic findings for colorectal cancer from GWAS in Asian and European American using the Asian GWAS consortium and GECCO
  
Cross talk between Parkinson disease and Cancer
  
Polymorphisms in Autophagy genes and the Risk of Colorectal Cancer.
  
Supplements, Diet and Genes in Colorectal Cancer Risk: A Genome-wide Approach
  
Multiple low penetrance colorectal cancer susceptibility alleles affect patient survival in the treatment of advanced disease
  
Genetic polymorphisms of catechol-O-methyltransferase (COMT) and colorectal cancer survival
  
Evaluating the increased cancer risk in patients with orofacial clefting – a systematic search for common genetic factors in genome-wide datasets
  
Additive and multiplicative gene-environment interactions for genetic predisposition to colorectal cancer
  
Phospholipase A2G1B Polymorphisms and Risk of Colorectal Neoplasia
  
Associations of Genetic Variation in Inflammation and Innate Immunity Pathways and Colorectal Cancer
  
Utilizing high-dimensional data with genome-wide scan data to identify novel genetic susceptibility variants for colorectal cancer
  
Marker-set based gene-environment interaction test for case-control studies
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