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GECCO
Areas of Interest
Sequencing
GECCO
Areas of Interest
Currently selected
GWAS
Sequencing
Survival
Tumor Characteristics
GxE Interactions
Risk Modeling
In the News
Sequencing
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GWAS
Recent
In the News!
Sequencing
Currently selected
Survival
Tumor Characteristics
GxE Interactions
Risk Modeling
In the News
Site Contents
Page Content
Sequencing
GECCO is extending the search for colorectal cancer risk loci to less-frequent and rare variants by conducting whole genome sequencing (~6x coverage) on a subset of samples (~4,000 samples). We aim to identify novel variants across the genome (aim 1) and to investigate gene-environment interactions (aim 2), while focusing on variants with a minor allele frequency of 0.01-5.0%. We will run both individual variant tests and aggregated variant tests. The sequence data will be used as a reference panel to impute the remaining GWAS data in GECCO, strengthening sample size and power to detect new loci.
Figure 1. Sequencing Grant Aims
Related Information
Colorectal cancer genetics research gets $13 million boost
(September 26, 2012)
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Calls:
Sequencing Annotation Meeting