GECCO is an international collaboration that focuses on the identification and characterization of genetic risk factors and gene-environment interactions for colorectal cancer (CRC). Furthermore, we are investigating the impact of germline genetic and environmental factors on the tumor genome. To translation of our findings into public health practice and clinical care, we are developing comprehensive risk prediction models that can personalize screening decisions.
The GECCO coordinating center manages individual level genetic and epidemiological data of over 130,000 participants from 70 studies from North America, Australia, Asia, and Europe. To date, we have harmonized over 100 lifestyle, environmental, and clinical variables across the studies. Germline genetic array-based data are available for all individuals (whole genome sequencing data are available for a subset) and targeted sequencing data are currently generated for over 5,000 colorectal cancer cases using tumor and paired normal DNA.
GECCO in the News : How inherited genes influence cancer immunity
"AACR 2017: Fuelling the 2nd Revolution in Cancer Research published by the Technology Network's Cancer Research Community